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BEATBox
24/7 home-cage operant conditioning that preserves natural rhythms while increasing data density and reproducibility.
BEATBox is an autonomous home-cage behavioral system that lets rodents live inside the experimental apparatus while continuously performing tasks.
By removing repeated handling, artificial session boundaries, and experimenter-driven timing, BEATBox preserves circadian rhythms, motivation, and long-term behavioral dynamics. The result is richer, more ecological data with higher reproducibility and lower animal stress.
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24/7 Home-Cage Operant Conditioning
BEATBox is an open, modular platform for continuous behavioral monitoring in a home-cage-like environment. Tasks, sensors, and reward modules can be configured to match experimental goals while minimizing handling and stress.



Transparent assembly video of the BEATBox enclosure
AssemblageCage_Transparent video.
Real photos to show BEATBox nearing deployment



Python software interface screenshots



Ecological validity with longitudinal, high-power datasets
Natural behavior is preserved by allowing animals to engage on their own schedule.
Track behavioral dynamics across days and weeks with stable conditions.
Autonomous engagement increases the number of trials per subject.
Minimal handling limits stress-related bias in behavioral readouts.
Richer within-subject datasets improve sensitivity and reproducibility.
Modular hardware with software-hardware co-design





V3 CAD render highlights










Controller boards, screens, and wiring details











In-lab recording
Short, real-life demo clip showing BEATBox in use.

BEATBox hardware and software are fully open-source, enabling inspection, adaptation, and replication across labs.

Join a growing community of behavioral neuroscientists, method developers, and engineers shaping next-generation home-cage experimentation.
BEATBox is developed by the NERB team: Eric Burguiere, Lizbeth Mondragon-Gonzalez, Daniela Domingues. Learn more at nerb.team.
For the team: nerbmouse@gmail.com
Centre de Recherche en Neurosciences de Lyon (CRNL), Located in: Centre Hospitalier Le Vinatier Address: CRNL - CH Le Vinatier - Bâtiment 462 - Neurocampus, 95 Bd Pinel, 69500 Bron